For more information, call the ATSDR Information Center at 1-888-422-8737. N ickel contam ination of intravenous fluids warrants concern, owing to three specific toxic effects o f Ni2+: (a) cardiac toxic ity , especially increased coronary artery resistance, (b ) oxytocic action on th e u terus, and (c) allergic reactions, since nickel is a common allergen. hardness and TOC on the acute toxicity of nickel to both Daphnia pulicaria and the fathead minnow (Table 6). The natural background levels of nickel in water are relatively low, in open ocean water 0.228– Nebeker et dl. Effects of nickel toxicity on photosynthetic pigments and dry matter yield of Cicer arietinumApril 03, 2018 L. (Chickpea) varieties were observed. This fact sheet is one in a series Nickel is widely distributed in nature, forming about 0.008% of the earth’s crust. The core of the earth contains 8.5% nickel, deep-sea nodules 1.5%; meteorites have been found to contain 5–50% nickel (5). The soluble compounds, such as nickel acetate, were the most toxic, and the insoluble forms, such as nickel powder, were the least toxic. The findings suggest that nickel be identified as a toxic air contaminant which may disproportionately impact children, pursuant to Health and Safety Code, Section 39669.5(c). Nickel as NiCl 2 was applied to the soil in solution form @ 0mgL-1(Control), 25mg L-1, 50mg L-1, 100mg L-1 and 150mg L-1. With both species, hardness was the only significantly correlated parameter. It is highly volatilized and readily dissociates in air. All the treatments were replicated six times. The toxic effects of nickel on the lung were recog-nized first by Agricola in the 16th century. Agency for Toxic Substances and Disease Registry Division of Toxicology ToxFAQs TM August 2005 This fact sheet answers the most frequently asked health questions (FAQs) about nickel. The key values are summarized below. Nickel is one of the most potent human allergens. The toxicity of nickel compounds appears to be related to the solubility of the compound. Animal toxicity Nickel carbonyl [nickel tetracarbonyl, Ni(CO)4] is a colorless liquid-metal compound (boiling point, 43) and was discovered by Mond and co- workers in 1890. NICKEL CARBONYL 13463-39-3 ACGIH: 0.05 ppm Ceiling as Ni NIOSH: 0.001 ppm TWA ; 0.007 mg/m3 TWA 2 ppm IDLH Our knowledge on the molecular mechanisms of nickel toxicity and carcinogenicity is sketchy. Several acute animal studies have reported soluble nickel sulphate as being the most toxic and insoluble nickel oxide the least toxic [2]. Some fatal cases were noted following exposure to nickel carbonyl, and by the early 1930s, nickel was a recognized cause of contact dermatitis. General toxicity The main target organ for nickel induced toxicity in animals is the respiratory tract [3]. Elevated incidences of lung and Inhalation The toxic effects of nickel result from its ability to replace other metal ions in enzymes, proteins or bind to cellular compounds (Cempel and Nikel, 2005), and among animals, micro-organisms and plants, nickel is reported by Nielsen (1980a) to interact with at least … (6) Chronic Effects (Noncancer): These mechanisms are likely to involve binding of nickel cation to tissue and cellular components, detrimental to their structure and function, and disruption of the homeostasis of essential metals. Page 5 of 10 Component Exposure Limits . Acute animal tests in rats have shown nickel compounds to exhibit acute toxicity values ranging from low to high. overall toxicity profile of nickel and its compounds, but do not contribute to the derivation of the RELs are described in Appendix A. 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